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In a preclinical investigation of the neuroprotective agent NXY-059, middle cerebral artery (MCA) embolization was implemented to instigate stroke in monkeys, yielding encouraging outcomes [29]
Inactivation of hyperactivated fibroblasts can also be achieved through the induction of cellular senescence, an approach that has been tested in models of arthritis (119, 120), where fibroblasts exhibit overactivation of their immune component and degradative properties
Neuroprotective strategies after neonatal hypoxic ischemic encephalopathy
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