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10.1073/pnas.0402763101 154
Some providers split the dose into two smaller injections per day (morning and evening) for sustained signaling, though once daily is most common
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Arrange a routine appointment if: Digestive side effects persist beyond 12 weeks without improvement Symptoms significantly impact your quality of life or ability to maintain adequate nutrition You're unable to tolerate the dose escalation schedule You experience unexplained weight loss beyond expected therapeutic effects New or worsening symptoms develop after the initial adjustment period Consider discontinuation and medical review if gastrointestinal symptoms are severe enough to affect your daily activities or nutritional intake
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