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Glucagon signalling, classically associated with raising blood glucose, also stimulates lipolysis in adipose tissue, increases mitochondrial activity in hepatocytes, and promotes whole-body energy expenditure

Keep a simple fitness log during your first month on medicationnote workout duration, intensity, how you felt, and any unusual physical responses

Take your injection on a day when you can rest if needed a small number of patients feel tired or mildly unwell in the first 24 hours as their body begins to respond

Very low calorie diets periodically, meal replacement programs, or intermittent fasting approaches may help some individuals maintain weight loss after tirzepatide discontinuation