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The closer proximity to the insertion point directs peptide toward the affected area
A recent study by Lius team demonstrated that the broad-spectrum DUB inhibitor palladium pyrithione complex (PdPT) promote GPX4 degradation, but proteasome inhibitor bortezomib reverses its effect (Yang L
Epub 2022 May 14
As a substance necessary for adipocytes differentiation, the reduction in GPX4 may affect AT remodeling, which is manifested by the finding that Gpx4 / AT mice have larger adipocytes and a considerably increased body weight compared to wild-type mice
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