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SNAC and C8 belong to the category of medium-chain fatty acid derivative chemical permeation enhancers (PEs), which act by protecting the API from degradation and enhancing permeation across a particular epithelial region of the GI wall
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For TRIUMPH-1, the focus on the 8mg and 12mg doses should produce results in the 22% to 25% range, with the possibility of exceeding 25% given that TRIUMPH-4 already showed 28.7%
GLP-1s may therefore complement biologics by targeting parallel inflammatory pathways and systemic drivers of disease
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