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GLP-1 receptor agonists and DPP4-inhibitor direct the T2DM therapies

Recall that Shc ultimately activates the MAPK pathway, while PLC has more metabolic effects including GLUT4 translocation

Novel mutations and decreased expression of the epigenetic regulator TET2 in pulmonary arterial hypertension

Additionally, the crossover design improves statistical efficiency, as the variance between participants is reduced, allowing for a smaller sample size while maintaining the ability to detect significant effects