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Management should be individualized based on symptom severity, patient tolerance, and treatment goals

In some people, thyroid autoimmunity is associated with persisting symptoms or lower quality of life even when thyroid hormones are in the normal range

45 Liver cytochrome P450 (CYP450) enzymes regulate the biotransformation of targeted agents (e.g., imatinib, erlotinib), and polymorphisms in these enzymes can result in therapeutic failure or toxicity

Alternatively, they must respond with an explanation, with supporting materials, if they do not believe they have violated regulations.Potential Consequences: Failure to address the violations may result in legal action, including product seizure or an injunction