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Gradually increasing the dose over a period of weeks lowers the risk of side effects and allows your body to get used to the medication

For those using oral contraceptives , precautions depend on which weight loss medication you're taking: With semaglutide (Wegovy) or liraglutide (Saxenda): No routine additional contraception is required based on product information With tirzepatide: Use a non-oral contraceptive method or add barrier methods (condoms) for 4 weeks after starting treatment and for 4 weeks after each dose increase If you experience vomiting or diarrhoea while taking oral contraceptives: If you vomit within 3 hours of taking your pill, follow the missed pill guidance for your specific pill type If you have severe diarrhoea lasting more than 24 hours, follow missed pill guidance Consider emergency contraception if you've had unprotected intercourse during this time Barrier methods alone (condoms, diaphragms) remain unaffected by weight loss medications but have higher typical-use failure rates (1318%) and require consistent, correct use

In the semaglutide arm, risk fell by about 4% per 5 kg lower baseline weight (HR 0.96), whereas this trend was not significant in the placebo arm

Weeks 5-16: The ramp-up to efficacy During this phase, the dose is gradually increased every few weeks