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The drug already shifts hydration through reduced thirst, GI losses (nausea, vomiting, diarrhea), and weight loss
alpha-arbutin alone may be insufficient for moderate-to-severe melasma in this population
However, rapid weight loss caused by reduced calorie intake can lead to some lean mass reduction if resistance training and protein intake are not prioritized
The fast losers are typically younger, have more weight to lose, started at higher body fat percentages, and often aren't training (meaning they're not preserving muscle, which makes the scale drop faster but the long-term outcome worse)
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