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Patients known to have two LDL-receptor negative alleles (little to no residual function) did not respond to REPATHA
Two forms of GLP-1 are secreted in response to a meal: GLP-1(1-37) and GLP-1 (7-36), but the predominant form in the circulation is the truncated form GLP-1(7-36) [7]
Ongoing Phase 2 research is evaluating combination therapy with PDE5 inhibitors for men with erectile dysfunction unresponsive to standard treatments
doi: 10.4103/1673-5374.169611 175 Schmidt-HieberC.JonasP.BischofbergerJ
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