Ideally, youd want labs done at the beginning and again with each dose increase, or at least every 36 months, to make sure the medication is working safely and not causing unwanted side effects
First, a substantial portion of the mechanistic and translational data derives from preclinical studies or small human cohorts, which may not fully capture understudied aspects of aging that vary across populations
Hwang C, Sinskey AJ, Lodish HF
The two glucagon-like sequences were rapidly synthesized by several groups, but neither the first, corresponding to the proglucagon 72108 sequence or the second, corresponding to proglucagon 126158 (it was predicted that the two final C-terminal amino acids, both basic, would be cleaved off during processing), had any effect on pancreatic insulin secretion (an early positive report of insulinotropic effects of PG 72108 at very high concentrations (10 7 mol/L) ( Figure 1 A first, the discovery of GLP-1 was met with moderate excitement