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Stem cell factor (SCF) and its tyrosine kinase receptor C-kit signalling pathways are critical for epidermal melanocyte development during embryogenesis[17, 20], notch signalling pathways are essential in the maintenance of adult melanocyte stem cells, and thus for melanocyte homeostasis[20], endothelin 1 plays a role in the differentiation of melanocyte precursors, and micropthalmia-associated transcription factor (MITF) with its cAMP response element play a critical role in melanogenesis[25]
Obesity Research
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