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Sanyal and colleagues conducted a phase 2a trial in MASLD that documented marked reductions in liver fat content following retatrutide exposure, anchoring its position in hepatic metabolic research (Sanyal et al., 2024, Nature Medicine)
The difference in concentration patterns (lower peaks, higher troughs) is modest enough that major safety divergence seems unlikely
He also had a normal BMI (22.8 kg/m 2 ) and good glycemic control (HbA1c 7%
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This research post is the original announcement
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