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The Institute for Clinical and Economic Review (ICER) found that among 11 large payers covering 57M lives, only ~70% of their GLP-1 policies met fair access criteria
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At the same time, elevated insulin and inflammatory cytokines suppress sex-hormone-binding globulin (SHBG) synthesis in the liver [2]
Large-scale clinical trials have demonstrated that GLP-1RAs predominantly exhibit neutral or suppressive effects on overall cancer risk, with semaglutide showing no elevated cancer incidence [14], while significant reductions have been observed in specific malignancies, particularly liver cancers and prostate cancers [13, 15]
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