retatrutide phase 2 nejm 2023 obesity trial jastreboff SURMOUNT-1 (NEJM 2022) tested tirzepatide — a dual GIP/GLP-1 receptor agonist — in 2,539 adults with and achieved up to 20.9% mean weight loss at the highest dose. 57% of participants 💉 Retatrutide may be redefining

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Your doctor will likely: Check your blood pressure at each visit Monitor your heart rate Test your kidney function with blood tests Track your weight and blood sugar Ask about side effects Consider getting a home blood pressure monitor

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Questi farmaci sono resistenti alla rapida degradazione da parte della DPP-4, ma poich presentano unanalogia di struttura solamente del 52% rispetto al GLP-1 endogeno, possiedono un maggior potere immunogeno con possibile sviluppo di anticorpi inattivanti