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503A compounding pharmacies compound according to specific patient prescriptions and are required by state boards of pharmacy to comply with standards. Because of the popularity and high demand of GLP-1 medications, Mir Ali, MD, bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA, worried this may drive some people to purchase their medication through a potentially unsafe option
The 2023 ADA guidelines recommend GLP-1 receptor agonists to reduce cardiovascular risk in individuals with a history of atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction and stroke (22)
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The literature also describes upregulation of growth factors involved in tissue repair, modulation of nitric oxide synthase activity, and effects on the dopaminergic and serotonergic systems that are harder to interpret clinically [Sikiric et al., Inflammopharmacology, 2018]
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