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*Eligible patients with a BMI of 30, or 27 with comorbidities, lost an average of 19% of their body weight (-33.6 lbs) in a 68-week clinical trial evaluating 2.4 mg semaglutide, when combined with a reduced-calorie diet and increased physical activity
In contrast, the GH-antagonist pegvisomant has been shown to improve glucose metabolism whether applied as monotherapy or added to treatment with somatostatin analogs (36)
Joshi, P
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