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For optimization targets and testing comparisons, we considered all available datasets from previously published plasticity experiments for glutamatergic connections in the juvenile rodent neocortex that used whole-cell paired recordings: layer 5 thick-tufted pyramidal cell (L5-TTPC) to L5-TTPC 12,14 , layer 2/3 pyramidal cell (L2/3-PC) to L5-TTPC 36 , L2/3-PC to L2/3-PC 41,43,44 , layer 4 pyramidal cell (L4-PC) to L2/3-PC 42 , layer 4 spiny-stellate cell (L4-SSC) to L4-SSC 41 (see Table 1)

Participants began with a starting dose of 0.25 mg per week for both cagrilintide and semaglutide, with the doses co-escalated every four weeks (to 0.5 mg, 1.0 mg, and 1.7 mg) until reaching the maintenance dose of 2.4 mg per week for each medication after 16 weeks

Frontiers in Pharmacology , 11, 592345

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