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A phase 2 study (MARIPOSA randomized trial) demonstrated that, in patients with OSA, administration of aroxybutynin (an antimuscarinic agent) combined with atomoxetine (a norepinephrine reuptake inhibitor) led to modest but significant reductions in AHI (AHI reduction of 5.9 events/hour greater than placebo) over a 4-week period, though the use of atomoxetine was also associated with a reduction of total sleep time by approximately 21 min

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supplement mechanisms remain largely theoretical Patients should also be aware of FDA warnings regarding compounded GLP-1 products, which have not been evaluated for safety, effectiveness, or quality

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Survodutide , a dual GLP-1/glucagon receptor agonist, takes yet another approach by leveraging glucagon's thermogenic properties

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