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After validation of effective degradation of TYR and subsequent melanin decrease, we evaluated the in vivo treatment efficacy on a mouse skin hyperpigmentation model, which was established by the implementation of 1,3-dihydroxyacetone (DHA)-based self-tanning drops and UV irradiation
This distinction fundamentally shapes its pharmacokinetic profile, granting it properties (oral bioavailability, protease resistance, BBB penetration) that most neuropeptides lack
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