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Reduced effectiveness despite consistent dosing can also indicate degradation, though this is harder to confirm objectively
DNase-I treatment showed more single colonies uniformly distributed on the surface, whereas CLSM images revealed amylase and Proteinase treatment showed a mixture of small and big clusters in biofilm architecture (Figure 3C)
If there is enough B12 at work in the cells, it keeps these two substances down, and the results of these tests will be low
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