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Data collection process The following information was compiled for each study: authors, year of publication, type of study, length of supplementation, a dose of supplementation and main effect
Here, we show that replacement of a single amino acid at position 973, just distal to the NPEY motif in the intracellular juxtamembrane region, from leucine, which is highly conserved in IRs, to phenylalanine, the highly conserved homologous residue in IGF1Rs, resulted in decreased IRS-1/PI3K/Akt/mTORC1 signaling and increased Shc/Gab1/MAPK cell cycle signaling
Avoid them within a 2-hour window of dosing
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