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After coronary artery ligation in mice, intraperitoneal T4 treatment upregulated cardiac ILK and Akt activity, enhanced early myocyte survival, and improved cardiac function establishing the mechanistic basis for the broader tissue-repair claims associated with thymosin beta-4 and its 1723 fragment TB-500
Although the drug was administered topically, systemic suppression of VEGF occurred, suggesting potential off-target effects beyond the ocular compartment (Sultana and Scondotto 2020)
Nature 508 (7495), 258262
This usually means the peptide is actively being absorbed
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