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Then, to determine whether the decreased levels of reduced GSH would affect sensitivity to artemisinin treatment, PfMRP1-mutant and PfDd2 parasites were pulse treated with different concentrations of DHA (100 700 nM) for 1 h and the PfMRP1 mutant was significantly more sensitive to DHA treatment compared to PfDd2 wildtype (Supp Fig 3C)
Dysregulation of these factors in the eye can lead to corneal melting and scarring with deleterious consequences
In ENLIVEN and other earlier clinical trials, pegozafermin had shown direct anti-fibrotic and anti-inflammatory effects on the liver, as well as reduced triglyceride levels, improved insulin resistance, and glycemic control, while continuing to demonstrate a favorable safety and tolerability profile
For more information on this drug class, please visit the ADAs Standards of Medical Care in Diabetes 2020 (source 7)
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