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Presented for research literature review only Varney JL et al

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Function of Nr4a orphan nuclear receptors in proliferation, apoptosis and fuel utilization across tissues

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Targeting the biology of aging with mTOR inhibitors

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Ex-4 modulates apoptotic pathways in the hippocampus through the regulation of the expression levels of Bcl2, Bax, and caspase-3 [71], and it improves mitochondrial function and integrity in AD mice through the PI3K/Akt signaling pathway [72]

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