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post-hoc factorial analysis showed body fat mass differed by -4.0% versus placebo (P=0.002), waist circumference dropped by 2.4 cm more than placebo, and daily energy intake was reduced by approximately 300 kcal compared to placebo

GLP-1R activation has a significant effect on glycemic control in patients with T2DM through a variety of mechanisms, including stimulation of insulin secretion, inhibition of glucagon secretion, protection of -cells from apoptosis, slowing gastric emptying and increasing satiety ( 2 GLP-1R GLP-1R is a G protein-coupled receptor (Wu et al., 2020) (Figure 1A)

This is where the concept of bioavailability becomes critical

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