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An observational study of obese T2D patients with concurrent MASLD (metabolic dysfunction-associated steatotic liver disease) showed that 12 weeks of liraglutide significantly increased gut bacterial diversity and shifted the community toward a profile more like healthy individuals ( Bacteroidota and Proteobacteria (class Bacilli also increased), whereas an active comparator (metformin) enriched different taxa ( Fusobacteria and Actinobacteria ) and had a larger effect on network connectivity of the microbiota

Genetics (2014) 198(4):160319

Ryter SW, Otterbein L, Morse D, Choi AM: Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance

Moreover, CR has been shown to protect against cognitive decline via upregulation of BDNF 30,39