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Difficulty breathing or other systemic symptoms
Tightly interconnected dense tumor tissues and a compact extracellular matrix are closely associated, the produced tissue pressure by physical barrier limits the complete permeation and hinders the infiltration of CAR-T cells in internal tumors [180]
Glutathione, on the other hand, tackles oxidative stress that accelerates aging
The azide handles were used for a strain-promoted click reaction with payloads, resulting in stable and homogeneous ADCs with tightly controlled DARs (predominant at 2 in most cases)
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