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20 Burns KD, Cherney D

Access this article Similar content being viewed by others Abbreviations ALD: Alcoholic Liver Disease NAFLD: Non-Alcoholic Fatty Liver Disease miRNA: Micro RNA AH: Alcoholic Hepatitis NASH: Non-Alcoholic Steatohepatitis MLCK: Myosin Light Chain Kinase IFN-: Interferon-gamma TNF-: Tumor Necrosis Factor-alpha IL: Interleukin CYP2E1: Cytochrome P450 2E1 MUCs: Mucin Proteins AMPs: Antimicrobial Peptides REG3G: Regenerating Islet-Derived protein 3 Gamma HA: Hyaluronic Acid PLVAP: Plasmalemma Vesicle-Associated Protein AUD: Alcohol Use Disorder LPS: Lipopolysaccharide KCs: Kupffer cells PAMPs: Pathogen-Associated Molecular Patterns TMA: Trimethylamine SCFAs: Short-Chain Fatty Acids CRIg: Complement Receptor of the Immunoglobulin Superfamily-Related Glycoprotein FMT: Fecal Microbiota Transplantation GLP-1: Glucagon-Like Peptide-1 LPL: Lipolysis FA: Fatty Acids DNL: De Novo Lipogenesis GHRP-6: Growth hormone-releasing peptide-6 GLP-1R: Glucagon-Like Peptide-1 Receptor CCL2: Chemokine (CC motif) ligand 2 NEFA: Non-esterified fatty acids NIAAA: National Institute on Alcohol Abuse and Alcoholism LG: Lipogenesis c-Met: Cellular-mesenchymal epithelial transition factor ROS: Reactive Oxygen Species Apaf-1: Apoptotic Protease Activating Factor-1 Irf3: Interferon Regulatory Factor 3 Ly6C: Lymphocyte Antigen 6 Complex, Locus C mALD: Murine ALD 7-Nec-1: 7-Chloro-O-Necrostatin-1 NF-B: Nuclear Factor kappa B ATP: Adenosine Triphosphate TXNIP: Thioredoxin Interacting Protein GSDMD: Gasdermin D ASH: Alcoholic steatohepatitis ACLF: Acute-on-Chronic Liver Failure GPX4: Glutathione Peroxidase 4 BMAL1: Brain and Muscle ARNT-Like 1 FTH: Ferritin Heavy Chain FPN: Ferroportin HO-1: Heme Oxygenase 1 SLC7A11: Solute Carrier Family 7 Member 11 HB: Hemoglobin SIRT1: Sirtuin 1 GSH: Glutathione ASK-1: Apoptosis Signal-Regulating Kinase 1 STAT: Signal Transducer and Activator of Transcription HPCs: Hepatic Progenitor Cells Th: Helper T cells NK: Natural Killer cell HSCs: Hepatic Stellate Cells G-CSF: Granulocyte Colony-Stimulating Factor DR: Ductular Reaction mTORC1: Mechanistic Target of Rapamycin Complex 1 TSC1: Tuberous Sclerosis Complex 1 KO: Knockout

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Abstract Glutathione (GSH) is a metabolite that plays an important role in the fields of pharmacy, food, and cosmetics