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(Left panel) Orange and green lines respectively displaying nonresponders (NR) and responders (R) log-ratio values of serum metabolomics of ImP during courses of immunotherapy (from visit T0 to T3)

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The PA form requests: Current BMI and weight history for the past 12 months Documentation of at least one obesity-related comorbidity (hypertension, type 2 diabetes, prediabetes, dyslipidemia, obstructive sleep apnea, cardiovascular disease, or nonalcoholic fatty liver disease) Proof of a "medically supervised weight loss program" within the past 6 months (defined as at least 3 documented visits with a provider or dietitian) Confirmation that the patient has tried and failed at least one other weight-loss intervention (medication, structured diet program, or behavioral therapy) The form is designed to be failed