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Indeed, with the exception of patients with HER2 -mutant NSCLC, current response rates preclude ADCs evaluation as first-line monotherapy, suggesting that enrichment of the population and/or a combination of approaches will be necessary

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For instance, observational studies show that taking vitamin E supplements is linked with an increased risk of prostate cancer and death by all causes ( Given the potentially adverse effects of vitamin E supplements, they cannot be recommended at this point