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Differentiated Thyroid Cancers (95-97% of cases) These arise from follicular epithelial cells that make thyroid hormone: Papillary thyroid carcinoma (PTC): 80-85% of thyroid cancers, excellent prognosis Follicular thyroid carcinoma (FTC): 10-15%, generally favorable outcomes Oncocytic (Hrthle cell) carcinoma: A follicular variant, relatively uncommon Medullary Thyroid Carcinoma (3-4% of all thyroid cancers) MTC arises from parafollicular C-cellscompletely different cells producing calcitonin, not thyroid hormone