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[72] Meta-analyses of melatonin for delayed sleep phase syndrome that found it effective have reported that it improves time to sleep onset by about 40 minutes (0.67 hours) and advances onset of endogenous melatonin secretion by about 1.2 hours (72 minutes)

After 104 weeks of treatment, 77% of patients maintained at least 5% weight loss, while approximately one-third achieved 20% or greater weight reduction ^3

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