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The topical route is the format with the strongest human clinical trial evidence for skin outcomes, from the landmark 1998 Abdulghani study that outperformed both vitamin C and tretinoin to the Finkley skin-thickness data

Some research suggests your body may not effectively use the pill

Bakuchiol: the plant-derived alternative Bakuchiol is a meroterpene from Psoralea corylifolia that produces retinol-like outcomes through completely different receptor pathways

Primary cells of the NVU may also be isolated in the laboratory (Bernas et al., via expression of the catalytic subunit of human telomerase (hTERT) and SV40 large T-antigen (Weksler et al., 2005)