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Captopril, an angiotensin-converting enzyme inhibitor, is widely used in clinical practice to treat hypertension, MI, and congestive heart failure and is effective in attenuating left ventricular (LV) dilatation, ameliorating LV ejection fraction and improving cardiovascular morbidity and mortality [237, 238]
They shouldnt, but they do
BPC-157 is known to be poorly bioavailable orally
For gut-wall local effects (ulcer healing, intestinal permeability), the peptide does not need to cross the gut epithelium into systemic circulation
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