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they can fall as much as 50 percent below optimal as we age
Clinical trials of GLP-1 receptor agonists have shown average reductions in daily energy intake of roughly 2030% during early treatment phases , reflecting the combined effects of increased satiety and reduced food preoccupation
43 Therefore, discontinuation of treatmentprimarily due to cost and access limitationsremains the major barrier to the widespread and sustainable use of these agents
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