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Moreover, B12 supplementation is really only relevant to reversing graying hair in the context of B12 deficiency

Studies have revealed that the GH/IGF-1 axis plays a key role in the aging process of humans and animals ( GH receptor is a member of the class I cytokine receptor family and exists in almost all cell types in the human body (Waters et al., 1999)

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By applying these inclusion and exclusion criteria, the review aimed to ensure the inclusion of relevant and high-quality studies that provide valuable insights into the role of oxidative stress, antioxidant interventions, and associated clinical trials in trisomy 21 or Down syndrome