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The animals were anesthetized by inhalation route with Isofluorane (Isboa Vet) using a vaporizer and intranasal administration was performed with two instillations of 20 l of the bacterial suspension prepared in PBS

When a nerve impulse reaches the synapse, it triggers the release of DA from synaptic vesicles into the synaptic cleft

Cagrilintide monotherapy produces about 11.8% reduction at 2.4 mg weekly