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doi: 10.1152/ajpheart.00574.2023 45
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The renal extraction and the natriuretic action of GLP-1 in Humans depend on interaction with the GLP-1 receptor
[8] Contemporary reviews emphasize that first-generation agents such as diphenhydramine are inverse agonists rather than simple antagonists and note emerging data on gene-dose effects, transporter interactions, and tolerance development, all of which should temper prolonged off-label use for insomnia
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