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Its weight-loss effects are primarily achieved through several mechanisms, including central appetite regulation via hypothalamic pathways enhancing satiety, delayed gastric emptying that prolongs postprandial fullness, improvement of insulin sensitivity and metabolic homeostasis, and reduction of visceral and hepatic fat depots, which may alleviate respiratory mechanical burden and metabolic stress in OSAS (34)

Tirzepatide Once Weekly for the Treatment of Obesity New England Journal of Medicine 387(3) 2022PMID: 35658024 NEJM 5 van Bloemendaal L, IJzerman RG, ten Kulve JS, et al

Patients sometimes describe the sensation as persistent motion sickness or a heavy stomach that never fully settles

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