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Comparative analysis demonstrates that while dihexa avoids standard enzymatic degradation better than traditional peptides, its primary stability challenge lies in managing solubility limits and preventing precipitation during storage
Third axis, genome-wide transcriptional modulation
NO activates soluble guanylate cyclase [174], resulting in the generation of cGMP, which in turn activates cGKI [175]
Moreover, integrated assessment of ROS levels, oxidase activity, and epigenetic alterations, including DNA methylation and histone modifications, may further elucidate the links among oxidative stress, HSP dysregulation, and male infertility
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