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Unlike medicines, they are not assessed for efficacy by the MHRA
10.1021/acs.molpharmaceut.9b01020 144 SuriS.GillS
Note that 2-PAM has an affinity for the acetylcholine anionic binding site on cholinesterase (right middle panel), which could explain the oxime related worsening of cholinergic side effects when 2-PAM is administered prior to the onset of action of atropine in the setting of organophosphate poisoning, by transiently preventing nerve-agent free cholinesterase from interacting with acetylcholine
10.1038/nm747 5 AyalaA.MuozM
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