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When tirzepatide was discontinued in another major trial, only 17 percent of participants held on to at least 80 percent of what they had lost

32-33 Patient-Centered Considerations When selecting between SGLT2 inhibitors and GLP-1 RAs, patient preferences and circumstances should be considered

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Alternatives include intensive lifestyle modification programs, other weight management medications like phentermine-topiramate or naltrexone-bupropion, different diabetes medications such as SGLT-2 inhibitors, and bariatric surgery for severe obesity