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Protein Regulation : Through thiol-disulfide exchange reactions, reduced glutathione modulates protein structure and function by reducing oxidized cysteine residues, maintaining proper protein folding and enzymatic activity

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Compared to the liver, we observed that the kidney has: (1) similar increased use of energy-related metabolites and production of urea cycle and ammonia-related intermediates, suggesting a shared catabolism in AKI, and (2) higher pools of energy metabolism intermediates in AKI