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TRIUMPH-CVOT: cardiovascular outcomes trial, approximately 10,000 participants with established CVD, primary endpoint major adverse cardiovascular events (MACE), timeline 3 to 4 years
Blocking NNMT is expected to raise SAM availability, but SAM participates in many cellular processes, so research must establish that selectively raising it does not perturb other methylation pathways
The treatment protocol usually extends over several weeks, with consistent administration being key to maintaining benefits
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