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Ferroptosis is defined by the accumulation of lipid peroxides and inactivation of glutathione peroxidase 4 (GPX4), and is typically initiated in the context of disrupted iron homeostasis, aberrant lipid metabolism, and mitochondrial dysfunction in the brain

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The importance of iNOS after gp120 exposure is partly derived from research demonstrating that iNOS inhibitors lessen a number of the negative effects of gp120