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PubMed, Embase, and the Cochrane Library were searched using keyword combinations related to GLP-1 receptor agonists, dual GLP-1/GIP agonists, and GI adverse events, from the inception of the database up to March 2025
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The strongest evidence in this domain supports the association between GHRH-related signaling, preserved pulsatility, and neuroendocrine rhythm research, but it's not definitive for this specific blend independently altering sleep architecture
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