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However, a much repeated criticism of studies of MSG taken without food is that the characteristic strong flavor of MSG is difficult to mask, unblinding the subjects to its identity and potentially leading to bias. Even in people who self-identify as MSG sensitive, studies have failed to provide reproducible evidence of an MSG effect. The authors of the largest and most comprehensive of such studies concluded that large doses of MSG given without food may elicit more symptoms than a placebo in individuals who believe that they react adversely to MSG
Its natural origin, ability to cross the blood-brain barrier, and multi-modal mechanismsimpacting oxidative stress, mitochondrial dysfunction, and immune dysregulationmake it a promising candidate for integrative treatment approaches
Available from: Barbosa CP, Farah O, Teixeira AC, et al
