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Toward disease-modifying therapies in type 1 diabetes: focus on teplizumab
Metabolic flexibility Although glutamine is the primary carbon source for the TCA cycle in some cancer cells, replenishment of TCA cycle intermediates using alternative anaplerotic substrates reduces bioenergetic stress, thereby enabling resistance to inhibition of glutamine metabolism
It also preserves the activity of antioxidants such as vitamins A, C and E
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