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This is also the case for those with exocrine pancreatic insufficiency (EPI)
Another group applied multi-omics analyses in PBMCs from RA patients at the start of anti-TNF- treatment and showed high expression of epiplakin 1 (EPPK1) and T-cell inhibitor chitinase-3-like 1 (CHI3L1) genes in those who responded [165]
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Because of its presence in blood and tissue fluids, it is considered a physiologic carrier of copper, with roles in signaling and tissue maintenance that remain under active investigation
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